I would like to let you know that after having ALL of the problems listed about this (Lockups, BSODs, poor performance) I found something that fixed all my issues.
I went to www.displaylink.com and downloaded the Nov 18th reference drivers from them and installed them.
My system has been stable without any extra "BIOS" modifications since. Before it was crashing everytime I was trying to load anything.
Just wanted to give a heads up on this one. Hopefully it helps someone.
System SPEC
Ryzen Threadripper 1950X
ASUS STRIX X399-E Gaming (808 bios)
GTX 1080 Ti (latest 417 drivers)
64Gb RAM (4X16Gb)
Windows 10